simFastBOIN: Fast Simulation of Bayesian Optimal Interval Designs for Phase I
Trials
Design and evaluate phase I dose-finding trials that use the
Bayesian optimal interval (BOIN) design of Liu and Yuan (2015)
<doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision
boundaries, to simulate trials, to estimate the dose-toxicity curve under a
monotonicity constraint and to select the maximum tolerated dose. The
simulation engine is written in C++ and draws one random variate per
patient in enrollment order, which reproduces the reference implementation
in the 'BOIN' package trial by trial for a given seed. The traditional 3+3
design is provided as a comparator, with operating characteristics obtained
in closed form rather than by simulation.
| Version: |
2.0.0 |
| Depends: |
R (≥ 3.5.0) |
| Imports: |
Rcpp (≥ 1.0.0), stats, utils |
| LinkingTo: |
Rcpp |
| Suggests: |
BOIN, ggplot2 (≥ 3.4.0), Iso, knitr, rmarkdown, spelling, testthat (≥ 3.0.0) |
| Published: |
2026-09-18 |
| DOI: |
10.32614/CRAN.package.simFastBOIN |
| Author: |
Gosuke Homma 
[aut, cre] |
| Maintainer: |
Gosuke Homma <my.name.is.gosuke at gmail.com> |
| BugReports: |
https://github.com/gosukehommaEX/simFastBOIN/issues |
| License: |
MIT + file LICENSE |
| URL: |
https://github.com/gosukehommaEX/simFastBOIN |
| NeedsCompilation: |
yes |
| Language: |
en-US |
| Materials: |
README, NEWS |
| CRAN checks: |
simFastBOIN results |
Documentation:
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