DANDELION: Discovery of Candidate Disease Genes Using Trans-Regulatory Effects

Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) <doi:10.1080/01621459.2021.1914634>. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.

Version:	0.1.0
Imports:	igraph
Suggests:	qvalue
Published:	2026-05-04
DOI:	10.32614/CRAN.package.DANDELION
Author:	Peixin Tian [aut, cre]
Maintainer:	Peixin Tian <pxtian at connect.hku.hk>
License:	GPL-3
NeedsCompilation:	no
Additional_repositories:	https://bioconductor.org/packages/release/bioc
CRAN checks:	DANDELION results

Documentation:

Reference manual:

DANDELION.html , DANDELION.pdf

Downloads:

Package source:	DANDELION_0.1.0.tar.gz
Windows binaries:	r-devel: DANDELION_0.1.0.zip, r-release: DANDELION_0.1.0.zip, r-oldrel: not available
macOS binaries:	r-release (arm64): DANDELION_0.1.0.tgz, r-oldrel (arm64): DANDELION_0.1.0.tgz, r-release (x86_64): DANDELION_0.1.0.tgz, r-oldrel (x86_64): DANDELION_0.1.0.tgz

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